Synthesis of Functionalized Quinolines Derivatives via Intramolecular C-H ActivationReactions of Isocyanides, Aniline and N-Sulfonylketenimine

A novel class of substituted quinolines was synthesized with good yields in a one-pot, four-componenttandem reaction by intramolecular C–H activation of isocyanides with N-sulfonylamidines, catalyzed by copper(I)iodide and L-proline as a ligand in acetonitrile at room temperature. The readily available starting materials, no needfor column chromatography, mild catalytic conditions and moderate to high yields, are important features of thissimple one pot reaction.

Keywords:

Copper catalysis , Quinolines , Sulfonylketenimines , Isocyanide , C–H Activation