Copper-Catalyzed One-Pot Synthesis of Functionalized Benzo[d]imidazo[۵,۱-b]thiazol-۱-amine Derivatives from Trichloroacetamidines, Benzothiazole and Terminal alkynes

A novel class of substituted benzo[d]imidazo[۵,۱-b]thiazol-۱-amine derivatives were synthesized with goodyields in a one-pot, four-component tandem reaction of benzothiazole, trichloroacetimidamide and terminal alkynesin acetonitrile at room temperature. Use of simple and readily available starting materials, one pot, no columnschromatography, copper-catalysts, good to high yields are important features of this protocol.

Keywords:

Benzo[d]imidazo[۵ , ۱-b]thiazol-۱-amine , Trichloroacetimidamide , Terminal alkynes , Benzothiazole.