Assessment of Cognitive Functions in Methadone Maintenance Patients
Publish place: Addiction and Health، Vol: 7، Issue: 3
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AHJK-7-3_004
تاریخ نمایه سازی: 12 مرداد 1403
Abstract:
Background: Methadone maintenance has received little scientific attention regarding neurocognitive effects. This study is aimed to assess the neuropsychological performance of methadone maintenance patients (MMP) compared to those healthy controls. Methods: Thirty-five MMP and ۳۵ healthy controls, matched for age, gender, education and employment status, examined on a battery of tests aimed at assessing verbal fluency, executive functions, verbal memory, and working memory, using controlled oral word association test (COWAT), trial making test (TMT) Part A and B, Rey auditory verbal learning test (RAVLT), and backward digit span. Findings: MMP performed significantly poorly than controls in cognitive domains of verbal fluency, executive function, and verbal memory. MMP did not exhibit impairment in working memory, and TMT Part A compared to controls. Conclusion: These results suggest that methadone consumption induces significant cognitive impairment that could compromise drug-treatment outcomes in MMP.
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Authors
Shahrzad Mazhari
Associate Professor, Neuroscience Research Center, Institute of Neuropharmachology AND Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Zeinab Keshvari
Resident, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Abdolreza Sabahi
Assistant Professor, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Shirin Mottaghian
General Practitioner, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran