Influence of menstrual cycle and salivary ß-estradiol on volatile sulfur compound

BACKGROUND: ß -estradiol is a steroid sex hormone that plays important role in oral physiology. The aim of this study was to determin the association of the menstrual cycle and salivary ß-estradiol with the production of volatile sulfur compounds (VSC).METHODS: In this cross-sectional study, twenty female dental students in good oral and general health were recruited for evaluation of VSC, salivary flow, ß-estradiol concentration, oral dryness feeling and dysmenorrhea. Data were analyzed by marginal homogeneity test and xtgee model.RESULTS: The only covariates that significantly related to VSC were being at the follicular phase (B = -۰.۲۱, P = ۰.۰۲), being at the pre-menstrual phase (B = -۰.۲۵, P = ۰.۰۱), stressfulness (B = ۰.۰۲, P = ۰.۰۱) and oral dryness feeling (B = ۰.۳۴, P = ۰.۰۲). Salivary ß-estradiol was at the level of ۵۹.۷ ± ۳۱.۲ in those having halitosis (VSC ≥ ۷۵) while in the others (VSC < ۷۵) it was about ۴۰.۸ ± ۱۸.۰ (P < ۰.۰۰۹). This difference was not statistically significant in multivariate analysis.CONCLUSIONS: The menstrual cycle, stress and oral dryness were the most important determinants of halitosis. The salivary ß-estradiol level could not explain such relationship as its effect was eliminated considering the other factors.

Keywords:

Halitosis , menstrual cycle , ß-estradiol , volatile sulfur compound