Investigating Clinicopathological Characteristics and Mitotic Index [MI] in Patients with Neuroendocrine Tumor of the Lung

Introduction: Most neuroendocrine tumor [NET] occurs in lungs, appendix, small intestine, rectum and pancreas. The main objective of this study was investigating clinicopathology in patients with neuroendocrine tumor of the lung.Methods: In this present study we evaluated clinicopathological characteristics of ۶۷ patients with lung neuroendocrine tumor reffered to our center from ۲۰۱۶ to ۲۰۲۱Results: The mean age was ۵۶.۶۲ years. Neuroendocrine tumors were more common in sixth decade [۳۵.۸%] of life.  ۷۶% were male and ۲۳.۹% were female. The most common types of neuroendocrine tumors were small cell lung cancer [SCLC], and typical carcinoid [TC] with frequencies of ۵۶.۳% and ۲۳.۴%, respectively. The frequency of large cell neuroendocrine carcinoma [LCNEC] and atypical carcinoid [AC] was ۱۰.۹% and ۹.۴%, respectively. So that typical carcinoid tumor was the most prevalent type in the fourth decade. However, SCLC and LCNEC tumors were more prevalent in the sixth decade, and ۷۰% of atypical tumors were prevalent in patients under ۴۰ years of age. TC, SCLC, and LCNEC tumors were more common in men compared to women. Besides, the average mitotic index in TC, AC, SCLC, and LCNEC tumors was ۲.۷%, ۷.۵%, ۷۵.۴%, and ۵۴.۱۶%, respectively.Conclusion: Our data revealed the clinicopathological status of neuroendocrine tumor of the lung. So, paying attention to the clinical condition, age, gender of patients in this regard helps in timely diagnosis of this disease.

Keywords:

Clinicopathology , Neuroendocrine tumor , Lung