The Association between TGF-β۱ G۹۱۵C (Arg۲۵Pro) Polymorphism and the Development of Primary Open Angle Glaucoma: A Case-Control Study

Abstract The purpose of the current study was to identify the potential association between Single Nucleotide Polymorphism (SNP) TGFβ۱ +۹۱۵ (C or G) in codon ۲۵ and Primary Open Angle Glaucoma (POAG). Overall, ۸۸ cases with POAG and a control group of ۵۲ healthy individuals were recruited from the First Ophthalmology Department of Athens University. DNA was isolated from whole blood samples and genotype frequencies for the polymorphism rs۱۸۰۰۴۷۱ (G۹۱۵C, Arg۲۵Pro) of the TGF-β۱ gene were assessed. Genotype distribution frequencies for the polymorphism rs۱۸۰۰۴۷۱ (G۹۱۵C, Arg۲۵Pro) of the TGF-β۱ gene were not statistically different between patients with POAG and control subjects. The present study failed to determine any significant genotypic association with POAG, despite the fact that the presence of the C allele was scarcely increased in the POAG when compared with the control group.