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Effect of levamisole on treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Publish place: Journal of Oral Health and Oral Epidemiology، Vol: 5، Issue: 2
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/2048274

شناسه ملی سند علمی:

JR_JOHOE-5-2_003

تاریخ نمایه سازی: 17 مرداد 1403

Abstract:

BACKGROUND AND AIM: The aim of this study was to systematically analyze the effect of levamisole on treatment of recurrent aphthous stomatitis (RAS).METHODS: An electronic search was executed in PubMed, Cochrane, and Scopus after determining the research question using the appropriate Medical Subject Heading (MeSH) term covering the period from ۱۹۷۵ to ۲۰۱۵. Additional publications from hand searching and the reference section of each relevant article enriched the article list. Finally, ۹ articles that have assessed the effect of levamisole on the treatment of RAS and had suitable qualifications for the accomplishment of systematic review and meta-analysis were included.RESULTS: The results showed that the chance of improvement in patients taking levamisole was ۶ [odds ratio (OR) = ۵.۶۷, ۹۵% confidence interval (CI)] times more than in patients not taking this drug.CONCLUSION: It appears that levamisole is an effective drug for the treatment of RAS, but further appropriate studies should carryout in this context.

Keywords:

levamisole , treatment , Aphthous , recurrent , stomatitis

Authors

Goli Chamani

Associate Professor, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical ‎Sciences, Kerman, Iran

Maryam Rad

Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research ‎Center, Kerman ‎University of Medical Sciences, Kerman, Iran

Mohammad Reza Zarei

Associate Professor, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical ‎Sciences, Kerman, Iran

Seyyed Reza Hashemimanesh

Dentist, Private Practice, Kerman, Iran

Elham Abbaszadeh

Resident, Department of Oral Medicine and Orofacial Pain, School of Dentistry, Kerman University of Medical Sciences, ‎Kerman, Iran

Masoumeh Sadeghi

PhD Candidate, Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, ‎Tehran, Iran

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