Salivary thiocyanate levels among tobacco users, non-users, and passive smokers: A biochemical study
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JOHOE-9-4_002
تاریخ نمایه سازی: 17 مرداد 1403
Abstract:
BACKGROUND AND AIM: The prevalence of tobacco use and its associated mortality is increasing worldwide. Biomarkers in saliva, such as thiocyanate levels, have been shown to be a suitable indicator for smoking. The present study is conducted to determine the thiocyanate levels in saliva and compare them among tobacco (smoking and smokeless) users, passive smokers, and non-smokers.METHODS: A cross-sectional comparative study was conducted on ۱۰۰ patients attending a dental college in South India. The patients were inquired about their tobacco habits and were divided into ۴ groups: smokers (۲۵), passive smokers (۲۵), smokeless tobacco users (۲۵), non-users (۲۵). Saliva samples were collected from subjects in sterile containers, and thiocyanate levels were estimated. The results were tabulated and analyzed using SPSS software. Kruskal-Wallis test was used for the intergroup comparison of salivary thiocyanate levels. Mann-Whitney U test was used for the pairwise group comparison. If P < ۰.۰۵۰۰, the results were reported to be statistically significant.RESULTS: The results of the study showed that the salivary thiocyanate level was ۷۹.۴۶ ± ۷.۸۰, ۵۰.۱۶ ± ۶.۸۷, ۵۰.۱۶ ± ۱۳.۸۳, and ۳۶.۶۱ ± ۵.۸۴ mmol/l among smokers, passive smokers, smokeless tobacco users, and non-users, respectively. There was a statistically significant difference in salivary thiocyanate levels among various groups (P ≤ ۰.۰۰۰۱). All pairwise comparisons showed statistical significance (P ≤ ۰.۰۰۰۱) except the comparison between the passive smokers and smokeless tobacco users groups (P ≤ ۰.۹۲۰۰).CONCLUSION: Salivary thiocyanate may be a diagnostic biomarker for differentiating tobacco users from the non-users.
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Authors
Anitta Benny
Postgraduate Student, Department of Periodontia, Mathrusri Ramabai Ambedkar Dental College, Bengaluru, India
Audrey Madonna D’Cruz
Professor, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Department of Public Health Dentistry, Mangalore, India