Molecular markers as an indicator in the malignant potential of oral lichen planus: A systematic review
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JOHOE-6-2_002
تاریخ نمایه سازی: 17 مرداد 1403
Abstract:
BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the databases PubMed, Google Scholar, Science Direct, Scopus, Cochrane and Thomson Reuters Web of Science (۱۹۹۰-۲۰۱۵) with the MeSH key words of: (“oral lichenoid reaction”, “oral lichenoid lesion”, “oral lichenoid eruption”, “oral lichen planus” “lichen planus”, “lichenoid”) AND (“malignant transformation”, “premalignant character”, “cancerization”, “pre-neoplasm”, “squamous cell carcinoma”). The reviewers screened the identified publications in three steps according to title, abstract and full text, extracted all the investigated markers in screened articles and finally classified the markers according to the frequency. Extracted data were saved in Excel software.RESULTS: Out of ۵۷۰ articles, ۶۶ were finally enrolled in the study. The most frequent evaluated markers were p۵۳, cyclooxygenase-۲ (COX-۲), Ki۶۷, B-cell lymphoma-۲ (Bcl-۲), Bax, p۲۱, and caspase-۳.CONCLUSION: The present study concluded that there were some documented evidences for association between malignant transformation of OLP and seven molecular markers (p۵۳, COX-۲, Ki۶۷, Bcl-۲, Bax, p۲۱, and caspase-۳).
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Authors
Zahra Atai
Associate Professor, Department of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
Zahra Khodadadi-Bohlouli
Dentist, Private Practice, Kerman, Iran
Nader Navabi
Associate Professor, Kerman Social Determinants on Oral Health Research Center, Kerman University of Medical Sciences, Kerman, Iran
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