Comparison of Dexamethasone and Hydrocortisone in Management of Exacerbated Chronic Obstructive Pulmonary Disease Patients; a Randomized Controlled Trial
Publish place: Journal of clinical care and skills، Vol: 4، Issue: 2
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 27
This Paper With 7 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CCS-4-2_003
تاریخ نمایه سازی: 8 شهریور 1403
Abstract:
Aims: Different corticosteroids with different characteristics, such as hydrocortisone and dexamethasone, have been used to treat exacerbated chronic obstructive pulmonary disease, but the drug of choice is unclear. The main goal of the present study was to compare the efficacy of hydrocortisone and dexamethasone on clinical symptoms, peak expiratory flow, oxidative stress factors, and inflammatory mediators in patients with exacerbation of chronic obstructive pulmonary disease.
Materials & Methods: In this single-blind randomized clinical trial study in ۲۰۲۱, ۷۰ eligible patients with chronic obstructive pulmonary disease exacerbations were selected and randomly divided into two A (۸mg of intravenous dexamethasone daily) and B (۲۰۰mg of intravenous daily hydrocortisone) groups. Clinical symptoms and peak expiratory flow were measured before intervention (day ۱), after intervention (day ۲), and on discharge day. However, oxidative stress factors and inflammatory mediators were evaluated on day one and discharge day. Moreover, the probable complications of both drugs were measured and scaled ۱-۴ by the researcher.
Findings: Between groups, comparisons showed significant differences in the patients’ clinical indicators for shortness of breath (p=۰.۰۲), sputum volume (p=۰.۰۱), and oxygen saturation of arterial blood (p=۰.۰۲). However, these differences were related to the first day, and no statistically significant differences were observed on the second or discharged days. The intragroup comparison revealed that the prescription of both dexamethasone and hydrocortisone led to significant improvement in the patient’s clinical symptoms.
Conclusion: Dexamethasone and Hydrocortisone are the same in improving important clinical symptoms and have similar efficacy on inflammation and oxidative stress in patients with COPD exacerbation.
Keywords:
Authors
A. Hosseini
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
A. H. Doustimotlagh
Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
A. Afrasiabifar
School of Nursing and Midwifery, Yasuj University of Medical Sciences, Yasuj, Iran
S. Sedaghattalab
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :