Effect of Aspirin on Pre-eclampsia and Fetal Growth Restriction in Obese Pregnant Women: A Randomized Controlled Clinical Trial
Publish place: Journal of clinical care and skills، Vol: 1، Issue: 4
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CCS-1-4_002
تاریخ نمایه سازی: 8 شهریور 1403
Abstract:
Aim(s): Obesity in pregnant women is a serious health problem that has many complications such as pre-eclampsia and fetal growth restriction (FGR). The aim of the present study was to evaluate the effect of aspirin on prevalence of pre-eclampsia and FGR in obese pregnant women.
Materials & Methods: This randomized controlled clinical trial was conducted on ۱۸۷ pregnant women referring to birth center of Mofatteh Clinic, Yasuj University of Medical Sciences, Yasuj, Iran in ۲۰۱۷-۲۰۱۸.
The subjects were selected using purposive sampling method and randomly divided into two groups; intervention group (n=۸۹) and control group (n=۹۸). The intervention group received ۸۰mg/day aspirin and the control group received placebo at ۱۳-۲۰ weeks of gestation until ۳۴ weeks of pregnancy. Data were analyzed by SPSS ۲۱ software using Chi square test.
Findings: The prevalence of pre-eclampsia (۱.۱ vs. ۱۱.۲) and FGR (۳.۴ vs. ۲۱.۴) were significantly lower in the intervention group compared to the control group (p<۰.۰۵).
Conclusion: Administration of ۸۰mg/daily of aspirin from ۱۳-۲۰ weeks of gestation in obese pregnant women reduces the incidence of pre-eclampsia and FGR, which could support the positive role of aspirin in preventing pre-eclampsia and FGR.
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Authors
R. Vanda
Gynecology & Obstetrics Department, Yasuj University of Medical Sciences, Yasuj, Iran
Sh. Aramesh
Gynecology & Obstetrics Department, Yasuj University of Medical Sciences, Yasuj, Iran
M. Sadeghian
Gynecology & Obstetrics Department, Valiasr Hospital, Bafgh, Iran
M.A. Ghatee
Cellular & Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
P. Ghaffari
Gynecology & Obstetrics Department, Yasuj University of Medical Sciences, Yasuj, Iran
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