Relationship between Vitamin D and Preeclampsia in Pregnant Women: A Comparative Descriptive Study

Aims: Pregnancy poisoning or preeclampsia is a serious and specific disorder of pregnancy that affects ۸% of the pregnant women. Similar studies conducted in this regard showed disagreement about the relationship between vitamin D deficiency and preeclampsia. Hence, the present study was conducted to evaluate the serum level of vitamin D in preeclampsia patients hospitalized in the maternity ward compared to healthy pregnant women. Instruments & Methods: This descriptive comparative study was conducted on ۱۸۰ pregnant women with a severe preeclampsia below the gestational age of ۳۳ weeks and ۲۰۰ non-preeclampsia pregnant women in Yasuj City from ۲۰۱۷ to ۲۰۱۹. Blood samples were taken from all subjects to measure vitamin D levels. The levels of ۲۵-hydroxy vitamin D were measured in the laboratory using the ELISA method. Data were analyzed using SPSS ۲۰ software. Findings: There was no significant difference between the preeclampsia group and healthy pregnant women in terms of mean levels of vitamin D (p=۰.۴۹). Preeclamptic women with normal level of vitamin D and vitamin D deficiency showed no significant differences in the mean of uric acid, systolic blood pressure, diastolic blood pressure, and the number of previous pregnancies (p>۰.۰۵). Conclusion: There is no relationship between serum vitamin D۳ levels and hypertensive conditions of pregnancy such as preeclampsia in pregnant women. Also, vitamin D۳ levels are insufficient in both groups.

Keywords:

Preeclampsia , Vitamin D , Proteinuria , Uric Acid