The Antibacterial Potential of Dillapional and Scopoletin Extracted from Foeniculum Vulgare

Fennel, a versatile plant, contains essential oil components such as trans-anethole, estragole, fenchone, and ۱-octen-۳-ol. The oil demonstrates antibacterial properties, combating bacterial infections and showing potential against drug-resistant microbes. Fennel's antimicrobial properties, along with its compounds Dillapional and Scopoletin, can contribute to developing innovative solutions for public health and addressing treatment for drug-resistant pathogens. We used online databases and software like PubChem and SwissADME to analyze the chemical composition of fennel and its bioactive compounds, such as trans-anethole, Dillapional, and Scopoletin. Dillapional and Scopoletin are low molecular weight compounds that can be easily absorbed during digestion and effectively cross the blood-brain barrier. They possess beneficial properties for treating meningitis. Both compounds demonstrate hydrophobicity and inhibitory effects on CYP۱A۲, a crucial detoxification enzyme. However, they are poorly absorbed through the skin. Their physicochemical and pharmaceutical properties, including solubility and blood-brain barrier permeability, make them worthy of further consideration for specific applications. Given the growing concern of antibiotic resistance, exploring natural sources like fennel and its bioactive components could lead to the development of novel and effective treatments against bacterial infections.

Keywords:

Foeniculum vulgare , Dillapional , Scopoletin