Synthesis of Functionalized Quinazolines Derivatives via theReactions of Isocyanides and Aniline-TrichloroacetonitrileAdduct

The synthesis of a novel class of substituted quinazolines derivatives via a one-pot, three-component,intramolecular C-H activation reactions of isocyanides and aniline-trichloroacetonitrile adduct catalyzed bycopper(I) iodide and L-proline as the ligand in MeCN at room temperature to good yields, has been reported.The use of simple and readily available starting materials, one pot, no column chromatography, mild coppercatalyticreaction conditions, and good to high yields, are important features of this protocol

Keywords:

C-H Activation , Trichloroacetonitrile , Copper-Catalyzed , Quinazolines , Isocyanides