Antibacterial activities of hydroalcoholic extract of Rosa canina L against Hospital Acquired Infections

Aim: Using the antimicrobial property of the extract of some medicinal plants as a substitute for antibiotics or alongside them can greatly help in the treatment of patients with hospital infections. This study aimed to determine and compare the antibacterial effect of hydroalcoholic extract of Rosa canina plant (Rosa canina L) on Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus bacteria isolated from surgical wounds in Yasouj hospitals. Methods: In this cross-sectional study, the effect of Rosa canina L hydroalcoholic extract on ۲۰ samples of Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus was investigated. the Minimum Inhibitory Concentration(MIC), Minimum Bactericidal Concentration(MBC) and zone of inhibition(ZOI) of each clinical sample were investigated and compared with the standard sample. the results were statistically analyzed by  ۲۱ SPSS software. Findings: Rosa canina L hydroalcoholic extract has no antibacterial effect on Pseudomonas aeruginosa. the lowest inhibitory concentration was related to Staphylococcus aureus ۱۲۵ µg/ml, Escherichia coli ۳۲۵ µg/ml and Klebsiella pneumoniae ۳۵۰ µg/ml, respectively. The difference in minimum MIC, MBC and ZOI between clinical and standard samples was not statistically significant. The ZOI diameter of Klebsiella pneumoniae and Escherichia coli clinical samples were equal (۹/۸ mm). Conclusion: The hydroalcoholic extract of Rosa canina L has a better antimicrobial effect on Staphylococcus aureus than other ۳ investigated bacteria and has no effect on Pseudomonas aeruginosa. There is no difference between the effect of the examined extract on clinical and standard samples, and the effect of this extract on different bacteria is different.

Keywords:

hydroalcoholic extract , Rosa canina L , antibacterial , bacteria