The Effect of Helicobacter Pylori Infection Eradication on Glomerular Filtration Rate in Patients with Chronic Kidney Disease

Background: Concomitant Helicobacter pylori (H. pylori) infection in patients with chronic kidney disease (CKD) may increase the risk of progression to end stage renal disease. Objective: We aimed to demonstrate whether eradication of this infection improves Glomerular Filtration Rate (GFR) in CKD patients. Methods: This is across-sectional cohort study  on ۲۷۰ CKD patients with GFR between ۳۰ to ۶۰mL/min who were evaluated for H. pylori infection. A total of ۷۹ patients were eligible for inclusion in the study. The patients underwent an early eradication treatment for H. pylori infection. The trend of changes in GFR was evaluated and compared in CKD patients in whome H. pylori infection was successfully eradicated (Group A) to those whose infection had not resolved (Group B) in a six month follow-up period. Results: In total, ۶۸ patients with CKD and a positive stool antigen test for H. pylori completed the study. When the mean GFR in CKD patients before and after treatment of H. pylori infection in the group A was compared, an upward trend was observed, increasing GFR from ۴۴.۶ ± ۱۰.۷ mL/min at baseline to ۴۷.۳ ± ۱۳.۶ mL/min at month ۶ (P-value=۰.۳). Although the observed difference was not statistically significant (P-value=۰.۳), that of the group B has a downward trend during the study, decreasing from ۴۶.۶ ± ۱۵.۷ mL/min at baseline to ۴۴.۸ ± ۱۴.۳ mL/min at month ۶. Conclusion: H. pylori infection eradication in CKD patients increases the GFR and concurrent H. pylori infection and CKD may complicate

Keywords:

Helicobacter pylori , H. pylori , Chronic kidney disease , Glomerular filtration rate , H. pylori Infection Eradication