Synthesis of azo compounds containing salicylic acid and its derivatives: A review

Azo compound derivatives, which are organic molecules with a double bond between two nitrogen atoms, have been extensively studied in scientific research. The predominant technique for producing these compounds entails the reaction between an aromatic amine and a diazonium salt. The synthesis usually employs starting materials such as salicylic acid, ۳-ASA, ۴-ASA, ۵-ASA, and its derivatives. The synthesis process initiates by transforming the amine group of the initial substance into a diazonium salt utilizing of sodium nitrite and hydrochloric acid. The subsequent stage involves a coupling process between the diazonium salt and salicylic acid or its derivatives. This paper specifically examines creating a diverse array of azo compounds, emphasizing their multiple uses as synthetic materials, artificial acceptors, molecular ligands, and agrochemicals. These chemicals demonstrate substantial biological action, namely in terms of their anti-inflammatory, antibacterial, antifungal, antiviral, and antidiabetic activities.

Keywords:

azo compounds , Diazonium salt , Aromatic amine , Salicylic acid derivatives , Synthesis , biological activities