Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats

Background & Objective:  Liver damage is a common complication of lithium (Li). The present study investigates the preventive role of MgSo4 and moderate-intensity training MIT on Li hepatotoxicity in male rats.  Materials & Methods:  Seventy-two male rats were distributed into 12 groups, control, Li10 mg/kg/day/ip, MgSo4 80 mg/kg/day/ip; MIT; Li40 mg/kg/day/ip; Li10+MgSo4; Li10+MIT; Li10+MgSo4+MIT, MgSo4+MIT, Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT. All animals were under the exercise protocol for 6 weeks and received the drugs daily. Then, a blood sample was taken from the heart to measure Cholesterol, Triglyceride, LDL, HDL, AST, and ALT. The liver was excised and then put in 10% formalin to be sent to the lab for pathological investigations. Results:  Compared to the control group, Li 10 and 40 mg/kg cause severe liver injury, p<0.05. Instead, MgSo4 and 6 weeks of MIT (Li10+MgSo4, Li10+MIT, and Li10+MgSo4+MIT), Li40+MgSo4, Li40+MIT, Li40+MgSo4+MIT, in comparison with Li10mg/kg and Li40 mg/kg, reduces damage and improves the liver function, p<0.05. Conclusion:  MgSo4 and exercise reduce Li-related, improved integrity together with liver function.

Magnesium Sulfate and Moderate-Intensity Training Improve Lithium-Induced Liver Injury in Male Rats Keywords:

Lithium , hepatotoxicity , magnesium sulfate , moderate-intensity training