Combination of N-Acetylcysteine and letrozole in Induction of Ovulation for Infertile Women with Polycystic Ovarian Syndrome

Background & Objective: Ovulation induction is considered the primary treatment for PCOS-related infertility. Clomiphene Citrate (CC) has usually been employed as the first-line medication, although letrozole has recently gained favor due to its improved efficacy in inducing ovulation. To assess the combination of N-Acetylcysteine (NAC) and letrozole in the induction of ovulation and the success of pregnancy for infertile polycystic ovarian syndrome patients.Materials & Methods: A double-blind random clinical trial was conducted in Babylon Governorate between ۲۰۲۳ and ۲۰۲۴, in which all patients referred to our hospital suffered from PCOS.Results: The size of the follicle in patients treated with letrozole + NAC was (۱۶.۶±۳.۳) mm, which was significantly larger than that (۱۵.۱±۳.۹) mm in group B (i.e., those treated by letrozole + placebo) (P=۰.۰۰۴). The induction of ovulation was probably considered in ۳۱ (۳۲.۳%) of patients in group A, while it was found in ۱۵ (۱۵.۶%) of patients in group B with a significant difference (P=۰.۰۰۶). Pregnancy success was significantly higher (P=۰.۰۲۹) in group A than in group B (۱۷ vs. ۷), respectively.Conclusion: Adding N-acetylcysteine to letrozole increased the induction of ovulation and success of pregnancy for infertile polycystic ovarian syndrome patients.

Keywords:

Polycystic Ovary Syndrome , N-acetylcysteine , Letrozole , Induction of Ovulation