Green Synthesis of Dimedone-Based Compounds under Ultrasonic and Reflux Conditions and Assessment of Their Anticancer Activity against A۲۷۸۰ Ovarian Cancer Cells

In this study, a series of dimedone derivatives were synthesized through the condensation of dimedone with various aromatic aldehydes. The chemical structures of the products were confirmed using spectroscopic techniques including FT-IR and NMR. The reactions were carried out under two different conditions: conventional reflux and ultrasonic irradiation. Additionally, the effect of varying the molar ratio of aldehyde to dimedone (۱:۱ and ۱:۲) was investigated. One of the advantages of this method is its solvent-free nature, contributing to a more environmentally friendly synthesis. The anticancer properties of the synthesized compounds were evaluated in vitro against A۲۷۸۰ ovarian cancer cells. Statistical analysis using SPSS revealed that treatment with ۲۵ µM and ۵۰ µM concentrations of all derivatives significantly reduced cell proliferation after ۲۴ hours compared to the control group (۰ µM). These findings indicate that all synthesized compounds exhibit promising anticancer activity.

Keywords:

Dimedone derivatives , Solvent-free synthesis , Ultrasound-assisted reaction , A۲۷۸۰ ovarian cancer cells , anticancer activity