ZSM-5-SO3H: an efficient and recyclable heterogeneous nanocatalyst for the Synthesis of naphthalene acetamide compounds under solvent-free conditions

ZSM-5-SO3H, a heterogenous catalyst, efficiently catalyzed the one-pot three-component Mannich reaction of aldehydes, acetamide, and 2-hydroxy naphthalene.This compounds were obtained in reasonable yields and excellent diasteroselectivity when the reaction was carried out under solvent-free conditions. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and nvironmentfriendly strategy for the synthesis of β-amino-ketones. The catalyst was recovered and reused for subsequent runs.

Keywords:

Mannich reaction , Heterogenous nanocatalyst , β-amino-ketones , Solvent free