Classifying Protein-Protein Interaction Type based on Association Pattern with Adjusted Support

Proteins carry out their functions by means of interaction.There are two major types of protein-protein interaction (PPI): obligate interaction and transient interaction. In this paper,residues with geographical information on the binding sites are used to discover association patterns for classifying proteininteraction type. We use the support of a frequent pattern as its inference power. However, due to the number of transientexamples are much less than the number of obligate examples,therefore there needs adjustment on the imbalance. Three methods of applying association pattern to classify PPI typeare designed. In the experiment, there are almost same results for three methods. And we reduce effect which is correct rate decreased by data type imbalance.

Keywords:

Protein-Protein Interaction , Association Pattern Based Classification , Type Imbalance