Preparation and Characterization of Fe3O4 Magnetic Nanoparticles Modified with Bio-compatible Copolymers Containing Methotrexate
Publish place: International Conference on New Research Findings in Chemistry and Chemical Engineering
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
View: 663
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
CHCONF01_017
تاریخ نمایه سازی: 20 دی 1394
Abstract:
The aim of this study is to develop new methods for the physical modification of super-paramagnetic nanoparticles Fe3O4 (SPIONs) by polymers through physical coating. These modified nanoparticles are used for the encapsulation of methotrexate which is used to treat cancer. In recent decades, the use of polymers in drug delivery, researchers have opened a new front. Magnetic nanoparticles mainly in medical advances, chemotherapy and targeted drug delivery to specific tissue repair has been used. In this research first biodegradable poly (D, L-lactic-co-glycolic acid) -poly ethylene glycol (PLGA-PEG-PLGA) were synthesized. Iron magnetic nanoparticles were prepared and detected using VSM, XRD, SEM, TEM and FT-IR methods. Magnetic nanoparticles coated with copolymer containing Methotrexate were prepared by a double emulsion method (w/o/w). This nanoparticles characterized via DLS,SEM and FT-IR analyzes. Drug encapsulation efficiency obtained 90%.Effect of pH and temperature on drug release was studied. The results showed that the synthesized copolymer is suitable for encapsulation of methotrexate and can effectively act as a new carrier in drug delivery and therapeutic target for anticancer drugs.
Keywords:
Authors
Sahar Jahangiri
Corresponding author: Student, M.Sc of Chemical Engineering, Department of Chemical Engineering, Faculty of Technical-Engineering, Ahar Branch, Islamic Azad University, Ahar, Iran
Abolfazl Akbarzadeh
Assistant Professor, Ph.D of Medicinal Chemistry, Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :