Pharmacological Evaluation of Sedative activity of methanolic extract of Thuja occidentalis in mice.
Publish place: International journal of Advanced Biological and Biomedical Research، Vol: 2، Issue: 1
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJABBR-2-1_024
تاریخ نمایه سازی: 26 اسفند 1394
Abstract:
The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping timeand elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg. The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarkable results as compared to the standard at both mentioned doses. Moreover, the extractsignificantly minimized onset of sleep and maximized the duration of sleeping time when administered with thiopental sodium and statistically it was significant (p < 0.05).
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Authors
Abdul Aziz
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Imran Ahmad Khan
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Musaddique Hussain
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan School of Pharmacy, The University of Faisalabad, Faisalabad, Pakistan
Muhammad Asif Raza
University Of Agriculture, Faisalabad (Sub campus Dera Ghazi Khan), Pakistan.