Caspase inhibition and natural neuron death
Publish place: 04th National Biotechnology Congress of Iran
Publish Year: 1384
Type: Conference paper
Language: English
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Document National Code:
NBCI04_332
Index date: 20 January 2008
Caspase inhibition and natural neuron death abstract
Programmed cell death (PCD) during which up to 50% of the neurons die in a certain period of time, occurs in the developing nervous system. Proteases, among them caspases, are known to be involved in cell death. To investigate if any specific protease(s) has a key role in PCD, chicken embryos were treated daily from E6-E9 with different protease inhibitors in this study. Among the inhibitors available in market, those for the caspase inhibition in general and for the inhibition of caspase 8, caspase 9 and calpain were used. Embryos were killed at E10 and neurons were counted in cilliary ganglia (CG). As expected, there was a significant increase in neuron numbers in CGs of embryos treated with a general caspase inhibitor. Interestingly, among the other CGs, there was a significant increase in neuron numbers only in those treated with caspase 9 inhibitor. These results suggest a key role of caspase 9 in the intracellular pathway of PCD.
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Caspase inhibition and natural neuron death authors
Azita Parvaneh Tafreshi
Department of Biochemistry, The national research centre for genetic enginering and biotechnology, Tehran
Bahman Zeynali
Department of developmental biology, Faculty of sciences, Tehran Universtiy.
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