Theoretical study on gold nanocluster (nAu=5, 6,7,9,11,12)conjugated to folat with 4-amino thiophenol as a linker for tumortargeted drug delivery
Publish place: چهارمین همایش ملی فن آوری های نوین شیمی و مهندسی شیمی
Publish Year: 1394
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
NCTCC04_202
تاریخ نمایه سازی: 19 اردیبهشت 1395
Abstract:
Nano science as a new scientific in various branches of science have been made many changes. Gold nanoclusters (AuNCs) provide non-toxic carriers for drug and gene delivery applications. An additional attractive feature of AuNCs is their interaction with thiols, providing an effective and selective means of controlled intracellular release. We also know that folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism. Now we have a folate connecting by the linker 4-amino thiophenol to three gold nanoclusters (AuNC).Folate is the generic term for folic acid and structurally related compounds that have the biochemical activity of folic acid. Due to folate’s promising characteristics of non-immunogenic, specificity for cancer, and its possible conjugation with gold nanoclusters (AuNC) as reported here, folate-AuNC nanoconjugate is a front-runner as a targeting moiety for many cancer nanotechnology treatments.
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Authors
Z Bayat
DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
M Hajipoor
DepartmentofChemistry,QuchanBranch,IslamicAzadUniversity-Quchan,Iran
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