Study on Reactions of quinazoline and pyridine Derivatives with Dialkyl acetylenedicarboxylate and Isoquinoline in the Different Condition

4-Hydroxyquinazoline and 2-hydroxypyridine undergoes a smooth reaction with dialkyl acetylenedicarboxylate in the presence of isoquinoline to produce the E/Z isomers of dialkyl 2-(4-oxoquinazolin-1(4H)-yl)but-2-enedioates and dialkyl 2-(2-oxopyridin-1(2H)-yl)but-2-enedioates. In this work we describes a fast, mild, convenient and simple method for preparing of nitrogen heterocycle derivatives by MCR reaction

Keywords:

Isoquinoline , Dialkyl acetylenedicarboxylate , E , Z isomers