Synthesis of 2-(N-morpholino methyl)-1-piperidino-1-phenyl cyclohexane as a newanalogue of phencyclidine

aryl cyclohexyl amines were synthesized for evaluation as central nervous depressants [1]. In this research, we synthesized 2-(N-morpholino methyl)-1-piperidino-cyano cyclohexane from 2-(N- morpholino methyl) cyclohexanone and KCN [2,2]. The new derivative of 1-aryl cyclohexyl amines was prepared from this nitrile by replacement of the cyano group by aryl using Grignard reagent [4]. The structure of nitrile compound and product of reaction this nitrile with Grignard reagent was confirmed by MASS,IR,12C-NMR,1H-NMR.

Keywords:

Phencyclidine , Amino nitriles , Grignard reaction