A comparative study on the effect of roughness andhydrophobicity of a polymeric surface on protein adsorption:a molecular dynamics study
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
View: 590
This Paper With 7 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
CHECONF03_272
تاریخ نمایه سازی: 14 آذر 1395
Abstract:
Specific protein adsorption can play a major role in eventual success or failure of biomaterials. As modern tissue engineering is going toward employment of polymeric scaffolds, the needs for evaluation of the interactions between polymer-protein systems become more vital. In this study molecular dynamics simulations are performed on 5 different amorphous polymeric surfaces to examine and compare theeffects of surface nano-scale roughness and hydrophobicity on the protein adsorption. In this regard, adhesion energy and final conformation of a subdomain of human serum albumin at the end of simulations are studied. Results indicate that effect of surface hydrophobicity on protein rearrangements and interactions with the surface is more dominant in comparison to the surface roughness.
Keywords:
Authors
Amir Shamloo
Department of Mechanical Engineering, Sharif University of Technology
Morteza Sarmadia
Department of Mechanical Engineering, Sharif University of Technology
Zahra Aghababaei
Department of Mechanical Engineering, Sharif University of Technology
Keykhosrow Firoozbakhsh
Department of Mechanical Engineering, Sharif University of Technology
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :