Efficacy of Mupirocin ointment to eradicate nasal Staphylococcus aureus in intensive care unit (ICU) staff and p
Publish place: سومین کنفرانس بین المللی پژوهش در مهندسی، علوم و تکنولوژی
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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RSTCONF03_314
تاریخ نمایه سازی: 6 بهمن 1395
Abstract:
Background Staphylococcus aureus is one of the most common causes of morbidity and mortality in ICU patients. The main way for distribution of this organism is nasal carriage personnel and patients. Aim The objective of this study was to evaluate the efficacy of mupirocin ointment to eradicate nasal S. aureus in intensive care unit (ICU) staff of Panjome Azar hospital, Gorgan, Iran. Methods In the first quarter, the prevalence of S. aureus was determined in ICU patients by routine microbiological methods and biochemical tests. The nasal samples were also obtained from all new patients admitted to the ICU as well as the ICU staff. Then, the mupirocin nasal ointment 2% was applied in persons with nasal carriage of S. aureus. After 5 weeks, a posttreatment sample was taken and examined. In the third step, during three next months the presence of S. aureus and its resistance to methicillin was evaluated in the new patients with the same method at the first step. Findings Out of 60 ICU staff participating in sampling, 7 staffs (11.7%) and out of 240 ICU patients, 2 patients were carriage for S. aureus. Of the 9 isolates, only 2 of them (22.2%) were methicillin-resistant S. aureus (MRSA).In first step (before intervention), only the 5 samples (2.8%) taken from the 120 patients were positive for S. aureus that 2 of them were MRSA, but in the third step (after the intervention), of the 120 samples no S. aureus was isolated. Conclusion Our finding showed that the application of mupirocin nasal ointment was highly effective for eradication of nasal carriage and in preventing nosocomial S. aureus infections in ICU.
Authors
Abolfazl Khandan del
PhD student in microbiology, Ayatollah Amoli Branch, Islamic Azad University , Amol , Iran
Ania Ahani Azari
Assistant Professor of Microbiology, Gorgan branch, Islamic Azad University, Gorgan, Iran
Behnaz Khodabakhshi
Infectious disease specialists, University of Medical Sciences, Gorgan, Iran
Ezzat Allah Ghaemi
Professor of Microbiology, University of Medical Sciences, Gorgan, Iran
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