Preparation and characterization of TMOS/PDMS Hybrid Material by the Sol-gel Process for drug delivery systems

In general, the sol-gel process may be described as ; the evolution of inorganic network through the formation of a colloidal suspension (Sol ) and gelation of the sol to form anetwork in a continuous liquid phase (gel) [1]. The sol–gel method is highly efficient due to the low temperature of the chemical process, high homogeneity andproduct purity[2]. These processes require the grafting of an organic component to an inorganic network by means of solgel process. In 1983 Unger and co-workers introduced the idea using solgel derived silica gel in drug delivery applications. In recentyears, sol-gel method has attracted many researchers (Shula Radin etal.,2009,T.Lopez et al., 2006, Thibaud Coradin et al., 2006, Katarzyna Czarnobaj et al.,2010).In this study Tetramethoxysilane (TMOS) was starting inorganic material and hydroxyl-terminated poly- (dimethylsiloxane) (PDMS-OH) provide a condensednetwork. The aim of the present paper was to develop an solgel matrices for the controlled release of drug substances.