Molecular insights into the pathogenesis and infection of Aspergillus fumigatus
Publish place: سومین کنفرانس بین المللی محیط زیست و منابع طبیعی
Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
View: 388
This Paper With 11 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
IENC03_001
تاریخ نمایه سازی: 11 مرداد 1396
Abstract:
The virulence of fungi is dependent on multiple factors, including the immune status of the patient and biological features of the fungi. In particular, the virulence of Aspergillus fumigatus is due to the complex interaction between various molecules involved in thermotolerance (such as ribosomal biogenesis proteins, α-mannosyltransferase and heat shock proteins), pigment production (DHN-melanin), immune evasion (such as melanin and hydrophobin) and nutrient uptake (such as siderophores and zinc transporters). Other molecules also play important roles in the virulence of A. fumigatus, including cell wall components and those that maintain its integrity (such as β-1-3 glucan, α- 1-3 glucan, chitin, galactomannan and mannoproteins) and adhesion (such as hydrophobins) and various hydrolytic enzymes (such as serine and aspartic protease, phospholipases, metalloproteinase and dipeptidyl peptidases). Signalling molecules (such as G-Protein, cAMP, Ras protein and calcineurin) also lead to increased virulence by altering the metabolic response to stress condition and toxins (such as gliotoxin, fumitremorgins, fumagatin and helvolic acid).
Keywords:
Authors
Siamak Ghazaei
Mohaghegh Ardabili University
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :