Evaluation of a Sentinel Lymph Node Biopsy with Patent Blue in Locally Advanced Gastric Cancer

Background: A sentinel lymph node (SLN) biopsy is an interesting issue in the field of surgical oncology andhas recently been introduced to the treatment of gastric cancer. The purpose of this study is to assess accuracy,sensitivity, specificity, and false negative rates (FNRs) of SLN biopsies, and to ascertain whether or not thisprocedure is useful for locally advanced gastric cancer.Methods: From December 2013 to March 2014, 22 patients with gastric cancer were enrolled in this study.After laparotomy, patent blue was injected around the tumor subserosaly, resection was then done, and SLNswere detected on a back table. Afterward, D2 dissection was carried out. Finally, SLNs and other specimenswere submitted for permanent pathology.Results: SLNs were detected in 20 of 22 patients. The total number of SLNs was 87. SLNs were positive in7 patients, and the total number of positive SLNs was 17. In three patients, the SLNs were negative, whereasother LNs were positive, with an FNR of 15%. 18 patients received neoadjuvant. Complete pathologicresponses with negative LNs were seen in 3 patients. Accuracy, sensitivity, specificity, and negative predictivevalues were 80%, 66%, 90%, and 76%, respectively.Conclusions: This research demonstrated that SLN mapping in advanced gastric cancer is an appropriatemethod with acceptable levels of accuracy, sensitivity, and negative predictive values, even in those patientswho received neoadjuvant treatment.© 2014 Tehran University of Medical Sciences. All rights reserved.Citation: Shirzadi A, Mahmoodzadeh H. Evaluation of a Sentinel Lymph Node Biopsy with Patent Bluein Locally Advanced Gastric Cancer. Acad J Surg, 2016; 3(1-2): 24-9.

Keywords:

Biopsy , Gastric cancer , Metastasis , Patent blue , Sentinel lymph node