Modified Fe2O3 magnatic nano particles application in carvedilol bioanalysis

A novel solid phase absorbent synthesized based on citric acid functionalized magnetic nano-particles modified by (3-amino propyl) triethoxysilane was developed. The obtaining nanosorbent has been characterized using FT-IR, scanning electron microscopy (SEM) and applied for the of carvedilol from spiked plasma samples. The developed nanosorbents was able to extract carvedilol from plasma and the extracted drug was successfuly analyzed in the range of 25–3000ng/mL (r > 0.9999) using HPLC method.

Keywords:

Plasma , HPLC , Carvedilol