Cu/c nanoparticles an efficient nanocatalyst for the synthesis of 8-amino coffeinyl hydroxyl alkyl derivatives
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CBGCONF04_284
تاریخ نمایه سازی: 22 دی 1396
Abstract:
The design and synthesis of 8-amino coffeinyl hydroxyl alkyl derivatives as analogues of cafaminol is described. The synthesis of these compounds was achieved in two steps. Initially, treatment of caffeine with N-bromosuccinimide afforded the prerequisite 8-bromocaffeine. Then, reaction of 8-bromocaffeine with different commercial and/or synthesized amine, epoxide and Cu/c nanoparticle as reaction catalyst was achieved to afford the corresponding 8-amino caffeine derivatives as potential chemotherapeutic agents in good to excellent yields.
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Authors
Bahman Eshaghi Nimvari
Department of chemistry, Shiraz University of Technology, Shiraz, Iran
Hamid Firoozi
Department of chemistry, Shiraz University of Technology, Shiraz, Iran