DBU promoted multi-component domino reactions for Synthesis of benzofurans in water
Publish place: National Congress on Chemistry and nano-chemistry, from research to national development
Publish Year: 1396
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
MRSS01_101
تاریخ نمایه سازی: 29 فروردین 1397
Abstract:
An efficient three-component strategy for the preparation of fused 2,3-dihydrofuran derivatives was developed with the assistance of N-hetocyclic compound ylide. The synthesis was achieved by reacting phenacyl bromides, Nheterocycles, aromatic aldehydes and cyclic 1,3-dicarbonyl compounds in the presence of a catalytic amount of DBU(1,8-Diazabicyclo(5.4.0)undec-7-ene) as an inexpensive, impressive and readily available catalyst in water under reflux. This strategy provides a rapid and efficient methodology for the preparation of benzofurans in excellent chemo-, regio- and stereoselectivities. This protocol has the advantages of convenient one-pot operation, short reaction times, high isolated yields of the pure products, easy work-up and avoidance of hazardous or toxic catalysts and organic solvents. Furthermore, it can be considered as environmentally friendly
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Authors
Elham Zarenezhad
Young Research and Elite Club, Darab Branch, Islamic Azad University, Darab, Iran