Synthesis of 3-amino-5-methyl-[1,1 -biaryl]-2,4-dicarbonitriles using ZnFe2O4 magnetic nanoparticles

This work studies an efficient, one-pot pseudo multi-component synthesis of 3-amino-5-methyl-[1, 1 -biaryl]-2, 4-dicarbonitriles. This reaction performed under solvent free conditions in the presence of ZnFe2O4 magnetic nanoparticles. The ZnFe2O4 nanoparticles were prepared by an eco-friendly hydrothermal method using aloe vera plant extract solution. Herein 3-amino-5-methyl-[1, 1 -biaryl]-2, 4- dicarbonitriles were synthesis via a simple reaction between the arylidenmalononitrile, malononitrile and sodium carbonate in ethanol at room temperature in the presence of ZnFe2O4 magnetic nanoparticles. Eco friendly, excellent yields of the product, short reaction time, inexpensive, and readily available starting material are the main advantages of this method.

Keywords:

Biaryl , Multi-component reaction , Nano ZnFe2O4 , Malononitrile , Aloe vera