Platelet-rich Plasma Eye Drops in the Healing of Post-Keratoplasty Persistent Corneal Epithelial Defects
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRAVOMED08_028
تاریخ نمایه سازی: 21 اردیبهشت 1397
Abstract:
Purpose: To investigate the effect of platelet-rich plasma (PRP) eye drops in the healing of post-keratoplasty persistent corneal epithelial defects Methods: Forty patients with persistent corneal epithelial defects following keratoplasty were treated with PRP eye drops four times a day. PRP eye drops were prepared with a low and high speed centrifuge method and final platelet counts were between 600000-800000 plt/μl for different ages and gender. Mean duration of treatment to complete epithelial healing was compared with mean duration of conventionally-treated corneal defects before the PRP treatment by paired t-test. Mean duration of treatment was also statistically analyzed between ages and gender by ANOVA test. P-value less than 0.05 considered statistically significant.Results: PRP eye drops led to rapid healing of persistent corneal epithelial defects in all patients. Mean duration of treatment to complete epithelial healing was 2.49 ± 1.23 weeks and was significantly less than the mean duration of conventionally-treated corneal defects before PRP treatment (6.82± 1.25wk) (P < 0.001). Mean duration of treatment was not statistically significant between different ages and gender (2.6 week in female versus 2.3 weeks in Male).Conclusion: Treatment with autologous PRP eye drops is an effective and reliable approach that accelerates healing of post-transplantation persistent corneal epithelial defects.
Authors
Sahar Balagholi
MSc,Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran .Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Scienc
Shaban Alizadeh
PhD, Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran
Alireza Baradaran-Rafiei
MD,Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Scienc