Continues Treatment with Lepidium Sativum Extract Improves Reproductive Behavior And Sperm Quantity In Adult Male NMRI Mice

The present study was undertaken to investigate effects of aqueous extract of the dried seeds of Lepidium sativum on reproductive behaviour and sperm count in adult male mice. Adult male NMRI mice were orally treated with three different doses of aqueous extract from Lepidium sativum (200, 400 and 600 mg/kg) for two weeks. After the treatment period, the sexual behaviours of the treated and control mice were evaluated using the receptive adult female mice, anxiety and depression levels of control and treated mice were evaluated using elevated plus maze (EPM) and forced swimming test, respectively. Serum and sperm samples were collected from each mouse. Serum testosterone, luteinising hormone (LH), and follicle-stimulating hormone (FSH) levels were analysed using Elisa kits, and the sperm quality was evaluated with HFT computer-assisted semen analysis (CASA) sperm analysing system. Obtained results reveals that treatment with the Lepidium sativum resulted increased level of testosterone and early phase of reproductive behaviours (sniffing, and following) and a higher number of spermatozoon and motile sperm count in comparison with the water-treated control group. According to results obtained in the current study, Lepidium sativum extrat affects elevates reproductive behaviour and improves sperm production

Keywords:

Lepidium Sativum , Mice , Sperm , Reproduction