Tetrabutylammonium bromide-Cesium carbonate: new reagent system for the synthesis of substituted pyridines at room temperature
Publish place: Iranian Chemical Communication، Vol: 4، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ICC-4-2_009
تاریخ نمایه سازی: 1 مرداد 1397
Abstract:
The highly substituted pyridine derivatives are found to exhibit diverse pharmacological activities.They are also emerged as potential medicinal leads in developing therapeutic agents for thetreatment of various diseases. In this work, a series of 2-amino-3,5-dicarbonitrile-6-thio-pyridinederivatives have been synthesized at room temperature via one-pot, multi-component reaction ofvarious aromatic aldehydes, malononitrile and thiophenols using catalytic amount of tetrabutylammoniumbromide (TBAB) and cesium carbonate in methanol. In the mentioned method, theuse of thermal condition is avoided. In addition, the advantages such as operational simplicity,economic viability, ecologically benign nature make this protocol a very efficient alternative tothe literature methods.
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Authors
Vinod T.Kamble
Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-۴۴۰۰۰۱ Maharashtra, India
Sandeep T.Atkore
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-۴۳۱۶۰۶Maharashtra, India
Parshuram M.Pisal
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-۴۳۱۶۰۶Maharashtra, India
Munazza Sadaf
Organic Chemistry Research laboratory, Department of Chemistry, Institute of Science, Nagpur-۴۴۰۰۰۱ Maharashtra, India