IL-17A gene polymorphism at position G197A and systemic lupus erythematosus
Publish place: Rheumatology Research، Vol: 3، Issue: 3
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RHRE-3-3_004
تاریخ نمایه سازی: 1 خرداد 1398
Abstract:
Systemic lupus erythematosus (SLE) is a multi-systemic disorder with various clinical manifestations. Lupus is a multifactorial autoimmune disease resulting from complex gene-environment interactions. IL-17 is a pro-inflammatory cytokine secreted by Th-17 cells, and IL-17A and IL-17F are two predominant members of this family. The present study assessed the association of IL-17F (rs763780) gene polymorphism with SLE. A total of 102 SLE patients and 141 healthy subjects were enrolled in this case-control study. Genotyping was done using the PCR-RFLP technique. The results were analyzed using SPSS software. Results showed a borderline relationship between the heterozygote genotype (AG) and a reduced risk of SLE (OR: 0.31, 95% CI: 0.09-1.0, P=0.05). The A allele was also shown as having a protective effect on SLE susceptibility (OR: 0.68, 95% CI: 0.46-1.0, P=0.05). No association was observed between the genotypes of the IL-17F gene polymorphism and the risk of SLE (P> 0.05). In conclusion, it seems that the IL-17A gene may be involved in the pathogenesis of SLE.
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Authors
Mahboobeh Sharifzadeh
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Sirous Naeimi
Department Of Genetics, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Mahboobeh Mahboobeh Nasiri
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Saideh Ariannia
Department of Rheumatology, Loghman e Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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