Methylprednisolone Versus Dexamethasone for Control of Vertigo in Patients with Definite Meniere s Disease: A Randomized Clinical Trial
Publish place: Iranian Journal of Otorhinolaryngology، Vol: 29، Issue: 6
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJOTO-29-6_006
تاریخ نمایه سازی: 12 تیر 1398
Abstract:
Introduction: Definite Meniere s diseaseis associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo. Materials and Methods: In this clinical study, 69 patients with definite Meniere s disease, referred to the tertiary otolaryngology center, were randomly assigned to two groups: 36 patients were treated with intratympanic dexamethasone (4mg/dl) and 33 patients were treated with intratympanic methylprednisolone (40mg/dl). Each group received three weekly injections. After a follow-up of 1 and 6 months, PTA changes and vertigo control were evaluated. Results: There was no statistically significant difference between the two groups with regard to control of vertigo (P=0.866, P=0.879 for 1 and 6 months post injection, respectively). PTA improvement was statistically significantly higher in the methylprednisolone group (P=0.006). Conclusion: In summary, intratympanic corticosteroid is an effective treatment for Meniere s disease and can prevent other invasive treatments. Intratympanic methylprednisolone can improve hearing level to a greater extent than intratympanic dexamethasone, but the two groups were similarly beneficial in controlling vertigo. However, there was a trend toward a more sustained benefit with methylprednisolone.
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Authors
Elham Masoumi
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Sasan Dabiri
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi Khorsandi Ashtiani
Otorhinolaryngology Research Center, Tehran University of Medical Siences, Tehran, Iran
Reza Erfanian
Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
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