Background: Burn injuries have negative impacts on health-related quality of life (HRQoL) of burn survivors. Thus, follow-up program is critical for burn patients caring. The present study aimed to determine the effects of follow-ups during a 12-month follow-up plan on HRQoL of burn survivors.Methods: This randomized clinical trial (RCT) is part of a large project. This study with a pre-test and post-test design by one intervention and one control group was carried out in Kermanshah from July 2016 to April 2018. A total of 101 participants were recruited and out of which 90 participants (45 for each group) were included in the groups. All subjects were assessed at discharge and 12 months after hospital discharge. After a year 43 participants remained in the study. The follow-up plan for the intervention group included home visits, tele-nursing, and referral to specialists in hospital. To evaluate the physical and psychological status of the patients, six different instruments were used; namely the Burn Specific Health Scale-Brief (BSHS-B), the General Health Questionnaire-28 (GHQ-28), the Brief Pain Inventory (BPI), the Vancouver Scar Scale (VSS), Goniometry, and the Visual Analogue Scale (VAS). All statistical analyses were performed by SPSS version 17. Data were analyzed using χ2, independent t-test, and paired t-test. P value less than 0.05 was considered statistically significant.Results: The mean score of the BSHS-B at discharge and 12 months post-discharge for the control and intervention groups was 60.71±18.85, 96.86±28.83; 55.04±18.80 and 129.72±16.64, respectively. There was a significant difference between groups at 12 months post-discharge follow-up (P<0.001). At 12 months, the VSS, GHQ-28 and BPI scores were improved in intervention group in comparison to the control group. After 12 months follow-up, the VAS score was 2.13±2.21, 4.55±3.20 in the intervention and control groups respectively and significant difference was found in VAS scores, (P=0.008). Conclusion: Follow-up program can improve HRQoL of burn survivors in areas of scar, psychological status, itching and pain. However scar management and itching require more attention because the scores were not in an ideal levels yet.