Simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by MgO NPs as an eco-safe catalyst

A clean and simple synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of magnesium oxide nanoparticles (MgO NPs) as an efficient and eco-friendly catalyst under thermal and solvent-free conditions with good yields and short reaction times is developed. This present methodology has notable benefits such as highly efficient, non-toxic catalyst, one-pot, solvent-free conditions, simplicity of operation with no necessity of chromatographic purification steps and eco-friendly.

Keywords:

Magnesium oxide nanoparticles (MgO NPs) , 1H-pyrazolo [1 , 2-b] phthalazine-5 , 10-dione derivatives , Solvent-free conditions , Multi-component reaction.