Bioconjugation of Interferon-alpha Molecules to Lysine-capped Gold Nanoparticles for further Drug Delivery Applications

Gold nanoparticles are potentially very attractive components for therapeutic delivery since they can be synthesized with any diameter from 1 to 200 nm to carry a payload of therapeutic molecules into a cell without triggering an immune response. Gold nanoparticles must undergo surface transformations before coupling to therapeutic molecules to become eligible for this purpose. It is increasingly being understood that amine groups can bind to gold nanoparticles strongly which has enabled surface modification of gold nanoparticles with amino acid lysine through its amine group. These lysine capped gold nanoparticles can further be coupled to therapeutic molecules for delivery purposes

Keywords:

Gold nanoparticles , Bioconjugation , Interferon-alpha , Lysine