Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi
Publish place: Avicenna Journal of Phytomedicine، Vol: 4، Issue: 3
Publish Year: 1393
نوع سند: مقاله ژورنالی
زبان: English
View: 263
This Paper With 9 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_AJP-4-3_002
تاریخ نمایه سازی: 1 مهر 1398
Abstract:
Objective: To investigate the anti-urolithiatic effect of aqueous extract of leaves of Bryophyllum pinnatum (B. pinnatum) on ethylene glycol-induced renal calculi. Materials and Methods: Thirty-six Wistar male rats were randomly divided into six equal groups. group A animals received distilled water for 28 days. Group B to group F animals received 1% v/v ethylene glycol in distilled water for 28 days and group B served as ethylene glycol control. Groups C and D (preventive groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively for 28 days. Groups E and F (treatment groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively from 15th to 28th day. On days 0 and 28, 24 hrs urine samples were collected for urinary volume and urinary oxalate measurement. On day 28, blood was collected for serum creatinine and blood urea level monitoring. All animals were sacrificed and kidneys were removed, weighed, and histopathologically evaluated for calcium oxalate crystals deposition. Results: Administration of aqueous extract of leaves of B. pinnatum reduced urine oxalate level significantly, as compared with Group B (p<0.001). Serum creatinine and blood urea level were improved significantly in all aqueous extract of leaves of B. pinnatum-treated groups. Relative kidney weight and calcium oxalate depositions were found significantly reduced in animals received ABP as compared with Group B (p<0.001). Conclusion: B. pinnatum is effective in prevention and treatment of ethylene glycol-induced urolithiasis.
Keywords:
Authors
Apexa Bhanuprasad Shukla
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-۳۶۴۰۰۱ (Gujarat), IndiaHospital, Bhavnagar-۳۶۴۰۰۱ (Gujarat), India
Divyesh Rasikbhai Mandavia
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-۳۶۴۰۰۱ (Gujarat), India
Manish Jasmatbhai Barvaliya
Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-۳۶۴۰۰۱ (Gujarat), India
Seema Natvarlal Baxi
Department of Pathology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-۳۶۴۰۰۱ (Gujarat), India
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :