The Evaluation of the Effect of Prenatal Copper Supplementation on Pregnancy Outcomes in Pregnant Women with Cupper Deficiency

Introduction: Copper (Cu) is an essential trace element for the body and seems to play an important rolein the final outcome of a successful pregnancy. Some studies have shown an increase in serum levels ofcopper in pathological pregnancies during the first trimester. This study aimed to evaluate the effect ofcopper supplementation in pregnant women was designed with copper deficiency on pregnancyoutcomes.Methods: This double-blind randomized controlled clinical trial on pregnant women with gestational ageof 16-12 weeks was conducted during 2014-2015. The copper levels measured in pregnant women, then120 qualified mothers have serum levels of copper at less than normal baseline values (120 μg / dL) havebeen selected. Data analysis with statistical software SPSS-21 and chi-square and independent t-test weredone.Findings: Of the 120 cases studied, 20 patients (16.6% of the total) had premature rupture of membraneswhich 6 women were in the case and 14 women were in the control group and statistical tests showed asignificant difference between the two groups (P=0.025). Also among the 120 cases studied, 23 patients(19.1% of total) with pre-eclampsia which 8 women were in the case and 15 women were in the controlgroup and statistical tests showed a significant difference between the two groups (P=0.034). Othervariables include spontaneous abortion, preterm delivery, placental abruption, low birth weight,intrauterine growth restriction, and intrauterine fetal death there was no significant difference between thetwo groups.Conclusion: Based on our findings, supplementation containing copper in pregnant women can reducethe risk of pre-eclampsia and premature rupture of the fetal membranes that Both can be seriousconsequences, such as infection of membranes, miscarriage or intrauterine death or life-threatening forthe mother.

Keywords:

Pregnancy , Copper serum level , Premature rupture of membranes