Systematic Review And Meta-Analysis Effect Of Vitamin D Supplementation With Anti-Viral Therapy On CD4 Levels In HIV-Infected Patients: Systematic Review And Meta-Analysis

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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JR_INTJMI-7-3_001

تاریخ نمایه سازی: 15 مهر 1398

Abstract:

Introduction: Due to the effect of vitamin D on the immune response, There are controversial resultsabout the effect of vitamin D supplementation on the immune system of AIDS patients. This systematicreview and meta-analytical was conducted to determine the effect of vitamin D supplementation, alongwith antiretroviral treatment on CD4 count of HIV-infected patients.Methods: This systematic review and meta-analysis study was done with using specific keywords HIVand vitamin D and CD4 and related keywords on published articles by the end of 2017 in the somedatabases such as Pubmed (116 articles), Scopus (121 articles) and Web of Science (127 articles). Allarticles have been export to ENDNOTE and after deleting duplicate, there was 174 articles. Reviewselected articles by two individuals, first on the title and abstract. Clinical trial studies about vitamin Dsupplementation on HIV-infected patients which receiving ART were selected. Quality assessment ofstudies was conducted by Jadad criteria. CD4 count and viral load before and after intervention intreatment and placebo groups, age of patients and duration of intervention were extracted.Fiundings: Finally, 7 clinical trial studies with a sample size of 639 people were entered the metaanalysis.The mean age of patients in the treatment group and placebo was 27.2 and 26.5 yearsrespectively, and mean duration of intervention was 8.3 months. The increase in CD4 after treatment was0.73 (CI95%:-0.43 - 1.89) compared with the placebo group which was not statistically significant, butVitamin D use in 3 studies was near one year and this change (SMD=3.56, CI95%: 1.17-5.96) wassignificantly in these studies. Egger s test results showed that there was no publication bias.Conclusion: The results showed that at least 10 months use of vitamin D supplementation with antiviraltherapy can effectively help in increasing the CD4 level in comparison with placebo.

Authors

Fatemeh Roozbeh

Mazandaran Uinversity of Medical Sciences, Sari, Iran

Maryam Ghajar

Mazandaran Uinversity of Medical Sciences, Sari, Iran