The Targeting of Autophagy and Endoplasmic Reticulum Stress Mechanisms by Honokiol Therapy
Publish place: Reviews in Clinical Medicine، Vol: 6، Issue: 2
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RCM-6-2_006
تاریخ نمایه سازی: 16 مهر 1398
Abstract:
In recent decades, special attention has been paid to cell death mechanisms, with the exception of apoptosis. This could be due to the resistance of cells, particularly cancer cells, to apoptosis. Among novel pathways, autophagy and endoplasmic reticulum (ER) stress have attracted the attention of researchers. A large number of antitumor drugs have been developed based on their modulatory effects on autophagy and ER stress. On the other hand, ER stress could stimulate autophagy and apoptosis, which is indicative of the dual role of this pathway. Therefore, the monitoring of these pathways could contribute to the treatment of pathological conditions. Among the multiple synthetic and natural modulators of autophagy and ER stress, natural agents are used more extensively owing to their few side-effects, valuable biological activities, and cost-efficiency. Honokiol as a lignin extracted from the bark of magnolia tree. This compound has been reported to have antioxidant, anti-inflammatory, anti-diabetic, and antitumor effects. The present study aimed to first introduce honokiol, autophagy, and ER stress and assess the modulatory effects of honokiol on the autophagy and ER stress mechanisms so as to demonstrate the therapeutic efficacy of this natural compound.
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Authors
Zahra Ahmadi
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar, Khuzestan, Iran
Sahar Roomiani
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar, Khuzestan, Iran
Niloofar Bemani
Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad Branch, University of Shushtar, Khuzestan, Iran
Milad Ashrafizadeh
Department of Basic Science, Veterinary Medicine Faculty, Tabriz University, Tabriz, Iran.
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