Determine Efficacy of a Short Course of Montelukast in Children with Intermittent Asthma and Viral Infection
Publish place: International Journal of Pediatrics، Vol: 1، Issue: 1
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_INJPM-1-1_004
تاریخ نمایه سازی: 20 مهر 1398
Abstract:
Introduction Mild intermittent asthma is common in children and viral infections are responsible for the majority of exacerbations. As leukotrienes are potent inflammatory mediators, some studies have shown that Montelukast, a leukotriene receptor antagonist, may be effective on reduction of asthma symptom. To determine whether a short course of Montelukast in asthmatic children with common cold would modify the severity of an asthma episode. Materials and Methods Children, aged 6-12 years with intermittent asthma participated in this randomized, double-blind, placebo-controlled clinical trial. Treatment with Montelukast or placebo was initiated at the onset of viral upper respiratory tract infection and continued for 7 days. Primary outcomes included the clinical manifestation: duration of episodes, daily symptom, nights symptoms and activity limitation. Secondary outcomes included the need for beta agonist usage, oral prednisolone, physician visit, hospital admission and school absence. Results A total of 187 children with intermittent asthma were randomized, 93 to Montelukast group and 94 to placebo group. Montelukast significantly decreased the cough by 17.3% (P<0.001), nighttime awakenings by 5.4% (P=0.01), interference with normal activity by 6% (P<0.01), time off from school by 6% (P<0.01), β-agonist usage by 17.2% (P<0.001) and doctor visits by12.2% (P<0.01) compared to placebo. Whereas there was a non significant reduction in wheezing, tachypnea, respiratory distress, asthma exacerbation, oral prednisolone and hospitalization (P=0.8). Conclusion A short course of Montelukast, introduced at the first sign of a viral infection, results in a reduction in cough, β-agonist use and nights awakened, time off from school and limitation of activity. More studies are needed to evaluate the optimal dose and duration of treatment.
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Authors
Hamid Ahanchian
۱Department of Pediatric Allergy-immunology, Mashhad University of Medical Science, Mashhad, Iran.
Fatemeh Behmanesh
۱Department of Pediatric Allergy-immunology, Mashhad University of Medical Science, Mashhad, Iran.
Hamid Reza Kianifar
۲Department of Pediatric Gastroenterology, Mashhad University Of Medical Science, Mashhad , Iran.
Nasrin Sadat Motevalli
۱Department of Pediatric Allergy-immunology, Mashhad University of Medical Science, Mashhad, Iran.
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